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Systemic Lupus Erythematosus (SLE), the lead indication for Ermium compounds, is a complex autoimmune disease, driven by dysregulations of both arms of the immune system, namely innate immunity, resulting in a major release of type I IFN and other pro-inflammatory cytokines, and adaptive immunity, involving both B and T lymphocytes. In that respect, breakthrough therapeutic innovations for SLE are likely to be achieved with novel drugs modulating both arms of the immune system simultaneously.
Ermium compounds, NCE to be orally administered, are efficiently and selectively downmodulating the activated immune system through the inhibition of a lysosomal protein leading to the downmodulation of lysosomal function and autophagy process.
The inhibition of this lysosomal target is acting upstream, thereby impacting downstream both:
Unique advantage to downmodulate different key immune dysregulations present in SLE patients through lysosomal function/autophagy modulation:
Orally administered compounds have a short washout period, so provide a safety advantage when stopping therapy compared to systemically administrated antibodies.
Proprietary Ermium compounds are derived from IT1t, a known CXCR4 antagonist, with immunomodulatory properties relevant for SLE patients. These properties were found subsequently to result from an innovative and well-differentiated mechanism of action (see above), that is independent of CXCR4.
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